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目的探讨宫颈癌患者血管介入化疗的临床效果。方法回顾性分析2010年5月至2012年5月内蒙古民族大学附属医院收治的宫颈癌患者80例的临床资料,所有患者均采用血管介入化疗方案治疗。结果本次选取的宫颈癌患者80例,完全缓解(CR)30例,占37.5%;部分缓解(PR)34例,占42.5%;无变化(NC)15例,占18.8%;进展(PD)1例,占1.2%,总有效率为80%。接受手术治疗的患者72例,改全程放疗的患者8例。在介入化疗过程中59例患者出现不同程度的消化道反应,对症治疗后症状缓解。3年生存率为90.0%,5年生存率为82.5%。在介入治疗后DNA含量、S期细胞比率(SPF)均明显降低,差异有统计学意义(P<0.05)。结论应用血管介入化疗方案辅助治疗宫颈癌患者,可以明显增加3年、5年的生存率,延缓病情发展,对保障患者预后有重要的意义。
Objective To investigate the clinical effect of vascular interventional chemotherapy in patients with cervical cancer. Methods The clinical data of 80 cases of cervical cancer admitted to the Affiliated Hospital of Inner Mongolia University for Nationalities from May 2010 to May 2012 were retrospectively analyzed. All the patients were treated with the interventional chemotherapy of vascular intervention. Results There were 80 cases of cervical cancer in this study. Thirty cases (37.5%) had complete remission (CR), 34 cases (42.5%) had partial response (PR), 15 cases (18.8%) had no change ) 1 case, accounting for 1.2%, the total effective rate was 80%. 72 patients underwent surgery and 8 patients undergoing full-length radiotherapy. In the interventional chemotherapy in 59 patients with varying degrees of gastrointestinal reactions, symptomatic relief after treatment. The 3-year survival rate was 90.0% and the 5-year survival rate was 82.5%. After interventional treatment, DNA content and S phase cell ratio (SPF) were significantly decreased, the difference was statistically significant (P <0.05). Conclusion The application of vascular intervention chemotherapy in the treatment of cervical cancer patients can significantly increase the 3-year, 5-year survival rate, delay the progression of the disease, to protect the prognosis of patients is of great significance.