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许多实验证明了柠檬酸铝抑制动物实验性矽肺的作用。本文讨论了正常及矽肺大鼠血清、尿、肺、肝、肾中铝的分布情况。 矽肺大鼠血清、尿、肺、肝、肾中的铝含量都低于对照组,由于矽肺大鼠肺重远远超过正常大鼠,因此矽肺大鼠全肺铝含量高于对照组。矽肺大鼠腹腔注射柠檬酸铝后,肺铝含量明显升高,而正常大鼠注射柠檬酸铝后,肝、肾铝含量明显升高。 矽肺及正常大鼠一次腹腔注射柠檬酸铝后(10mg Al/kg体重),药物动力学观察发现,矽肺组铝的吸收及分布均较慢。 研究以上这些差异对讨论矽肺的发生和发展有一定的意义。
Numerous experiments have demonstrated that aluminum citrate inhibits experimental silicosis in animals. This article discusses the normal and silicosis of serum, urine, lung, liver, kidney distribution of aluminum. The content of aluminum in serum, urine, lung, liver and kidney of silicosis rats was lower than that of the control group. Because the lung weight of silicosis rats far exceeded the normal rats, the content of aluminum in the whole lung of silicosis rats was higher than that of the control group. After aluminum citrate was injected intraperitoneally into silicosis rats, the content of pulmonary aluminum was significantly increased, whereas the content of aluminum in liver and kidney was significantly increased after aluminum citrate injection in normal rats. Silicosis and normal rats after intraperitoneal injection of aluminum citrate (10mg Al / kg body weight), the pharmacokinetic study found that the absorption and distribution of aluminum in the silicosis group are slow. It is of some significance to study the above differences to discuss the occurrence and development of silicosis.