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对恶性肿瘤晚期病人的止痛,自1979年Wang氏和Behar氏提出吗啡注入椎管内止痛获得成功之后,硬膜外腔注射小剂量阿片类和局麻药止痛已较多的用于临床。为了探讨恶性肿瘤骨转移病人硬膜外止痛问题,我们采用了丝裂霉素硬膜外腔注射对恶性肿瘤晚期椎管内转移病人的止痛,此方法国内外尚未见有报道。我科自建立疼痛病房共收治14例晚期癌症病人,其中3例为椎管内转移癌病人,用硬膜外腔留置导管,注射丝裂霉素止痛和1例肝癌晚期;右侧坐骨转移癌瘤内留置导管,注射丝裂霉素止痛均获得满意效果,现报告如下:
For the analgesia of patients with advanced malignant tumors, since the success of morphine injected into the spinal canal for pain relief in 1979 by Wang and Behar, low-dose opioid injections and local anesthetic analgesia have been used more frequently in clinical settings. In order to investigate the epidural analgesia in patients with metastatic bone metastases, we used mitomycin C epidural injection to relieve pain in patients with advanced malignant spinal metastases. This method has not been reported at home and abroad. In our department, 14 cases of advanced cancer patients were treated in the establishment of a pain ward. Among them, 3 cases were patients with spinal metastases, catheters were placed in the epidural space, mitomycin analgesia was given, and 1 case of advanced hepatocellular carcinoma; right ischial metastases. The indwelling catheter and the injection of mitomycin for pain relief all achieved satisfactory results. The report is as follows: