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目的探讨血清肝素结合表皮生长因子样生长因子(HB-EGF)水平对冠状动脉支架内再狭窄的影响。方法选取2009～2010年在淮北市矿工总医院复查造影的既往接受PCI术患者80例进行研究。以支架内狭窄≥50%为再狭窄标准,将患者分为再狭窄组36例及非再狭窄组44例。所有患者均于造影前采空腹血,测定血清中HB-EGF水平。结果再狭窄组血清HB-EGF水平显著高于非再狭窄组,差异有统计学意义(P<0.05),多因素Logistic回归分析显示:血清中HB-EGF水平的B:0.112,OR:1.025,95%CI:0.989～1.250(P<0.05)。结论血清中HB-EGF水平升高促进了支架内的内膜增殖及血管重构,是冠状动脉支架内再狭窄的危险因素之一。
Objective To investigate the effect of serum heparin-binding epidermal growth factor-like growth factor (HB-EGF) on coronary stent restenosis. Methods From 2009 to 2010 in Huaibei Miners General Hospital review of contrast 80 patients with previous PCI surgery were studied. Patients were divided into restenosis group (n = 36) and non-restenosis group (n = 44) according to the standard of stenosis≥50%. All patients underwent fasting blood before angiography, and serum HB-EGF levels were measured. Results The level of serum HB-EGF in restenosis group was significantly higher than that in non-restenosis group (P <0.05). Logistic regression analysis showed that HB-EGF level in serum was 0.112, OR was 1.025, 95% CI: 0.989 to 1.250 (P <0.05). Conclusion The elevated level of HB-EGF in serum promotes the intima proliferation and remodeling in the scaffold, which is one of the risk factors for restenosis in coronary stents.