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目的观察全身联合呼吸道局部应用激素治疗慢性阻塞性肺病(COPD)急性加重期的临床效果。方法选取我院自2008年3月至2010年5月收治的87例COPD急性加重期患者随机分为观察组(联合用药组)45例和对照组(无局部用药组)42例,比较两组患者的治疗效果。结果①观察组治愈32例,显效11例,总有效率为95.6%;对照组治愈25例,显效12例,总有效率为88.1%。两组比较差异显著(P<0.01),具有统计学意义。②两组患者治疗后肺功能各项指标均较治疗前有显著改善(P<0.01),但观察组改变较对照组明显(P<0.01)。结论全身联合呼吸道局部应用糖皮质激素治疗AECOPD效果理想,可以显著改善肺功能状态、提高治疗效果,值得推广应用。
Objective To observe the clinical effect of systemic topical application of hormones in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Eighty-seven patients with acute exacerbation of COPD who were admitted to our hospital from March 2008 to May 2010 were randomly divided into observation group (45 cases) and control group (42 cases without local treatment group), and the two groups were compared Patient’s therapeutic effect. Results ① The observation group cured 32 cases, markedly effective in 11 cases, the total effective rate was 95.6%; control group, 25 cases were cured, markedly effective in 12 cases, the total effective rate was 88.1%. The difference between the two groups was significant (P <0.01), with statistical significance. ② The indexes of pulmonary function in both groups were significantly improved after treatment (P <0.01), but the changes in observation group were more obvious than those in control group (P <0.01). Conclusion The application of topical glucocorticoid in treatment of AECOPD in systemic combined with respiratory tract is effective, which can significantly improve the pulmonary function status and improve the therapeutic effect, which is worth popularizing and applying.