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急性冠状动脉综合征（ ACS）产生动脉粥样硬化斑块，而斑块破裂可引起继发性栓塞。 ACS的发病率和病死率均较高，寻找高效的生物标志物进行早期诊断是亟待解决的问题。妊娠相关血浆蛋白A（PAPP-A）虽然是在孕妇的血浆中发现并初步研究的，但作为蛋白水解酶，PAPP-A 可水解胰岛素样生长因子结合蛋白4和胰岛素样生长因子结合蛋白5，产生胰岛素样生长因子，促进 ACS的发生、发展，是ACS检测的重要生物标志物。“,”Atherosclerotic plaques is found in acute coronary syndrome(ACS),rupture of which could lead to secondary embolization.The morbidity and mortality of ACS are both high.Finding an effective bio-marker for early diagnosis is imminent .Since found in serum of pregnant women firstly ,pregnancy associated plasma protein A ( PAPP-A ) was being investigated and it was noticed that as the proteolytic enzyme , PAPP-A could hydrolyze insulin-like growth factor binding protein4(IGFBP-4) and IGFBP-5 to make insu-lin-like growth factor(IGF),which then promote ACS.PAPP-A could be regarded as an important biomarker for test of ACS.