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目的探讨窒息新生儿尿微量白蛋白(mAlb)和转铁蛋白(TRF)水平的变化及临床意义。方法取61例窒息新生儿(轻度窒息32例,重度窒息29例)及35例无窒息及严重感染性疾病的同期住院新生儿生后24h尿液作mAlb和TRF检测;同时取血查肌酐(Cr)、尿素氮(BUN)进行对照。结果窒息组尿mAlb、血Cr浓度及尿TRF异常率均较对照组明显升高,而重度窒息组尿mAlb、血Cr浓度及尿TRF异常率则较轻度组明显升高,均有极显著性差异(p<0.01)。但血BUN浓度在各组间比较差异均无统计学意义(p>0.05)。结论尿mAlb、TRF升高与新生儿窒息程度及肾损害密切相关,是窒息新生儿早期肾功能监测灵敏、有效的指标。
Objective To investigate the changes and clinical significance of urinary albumin (mAlb) and transferrin (TRF) levels in neonates with asphyxia. Methods Thirty-six neonates with asphyxia (32 with mild asphyxia and 29 with severe asphyxia) and 35 with neonatal asphyxia and severe infectious diseases were tested for mAb and TRF 24 hours after birth. At the same time, serum creatinine (Cr) and urea nitrogen (BUN). Results The levels of urinary mAlb, blood Cr and urinary TRF in asphyxia group were significantly higher than those in control group, while the levels of urinary mAlb, blood Cr and urine TRF in severe asphyxia group were significantly higher than those in mild group Sex differences (p <0.01). However, there was no significant difference in serum BUN between the groups (p> 0.05). Conclusion The increase of urinary mAlb and TRF is closely related to neonatal asphyxia and renal damage, which is a sensitive and effective indicator of early renal function monitoring in asphyxia neonates.