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[目的]研究HIV-1感染相关的CCR2-64I及SDF1-3’A等位基因在广西壮、汉族人群的突变频率和多态性特点。[方法]抽取广西天等县、南宁市100名壮族和50名汉族人,提取全血基因组DNA,采用PCR-限制性片段长度多态性(PCR-RFLP)方法检测CCR2-64I和SDF1-3’A的基因多态性,分析CCR2-64I及SDF1-3’A等位基因在研究人群中的分布及其特征。[结果]壮族、汉族人群中CCR2-64I等位基因突变频率分别为25.5%、26.0%,SDF1-3’A等位基因突变频率均为27.0%,CCR2-64I和SDF1-3’A等位基因突变频率在壮、汉族之间差异无统计学意义(P﹥0.1)。[结论]广西壮、汉族人群中具有较高的CCR2-64I及SDF1-3’A等位基因。本研究了解广西壮、汉族人群中CCR2-64I和SDF1-3’A等位基因的分布和多态性特点,为进一步深入研究广西壮、汉族人群的遗传背景与HIV感染及疾病病程的关系提供了重要数据。
[Objective] To investigate the mutation frequency and polymorphism of CCR2-64I and SDF1-3’A alleles associated with HIV-1 infection in Zhuang and Han populations of Guangxi. [Methods] A total of 100 Zhuang and 50 Han nationality were sampled from Tianbian County, Nanning City, Guangxi Province. Whole genomic DNA was extracted. PCR-RFLP was used to detect CCR2-64I and SDF1-3 ’A gene polymorphism, analysis of CCR2-64I and SDF1-3’A allele distribution in the study population and its characteristics. [Results] The frequency of CCR2-64I allele mutation was 25.5% and 26.0% respectively in Zhuang and Han nationality population. The frequencies of allele frequency of SDF1-3’A allele were 27.0%, CCR2-64I and SDF1-3’A allele The frequency of gene mutation was no significant difference between Zhuang and Han (P> 0.1). [Conclusion] There are high CCR2-64I and SDF1-3’A alleles in Zhuang and Han nationalities in Guangxi. This study was to investigate the distribution and polymorphism of CCR2-64I and SDF1-3’A alleles in Zhuang and Han populations of Guangxi Zhuang and Han so as to provide a further study on the relationship between genetic background and HIV infection and disease course in Guangxi Zhuang and Han nationality The important data.