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目的:探讨不同手术方式治疗峡部甲状腺乳头状癌（PTCI）效果及对甲状旁腺功能和甲状腺球蛋白（Tg）的影响。方法:选择浙江新安国际医院于2016年1月至2021年1月治疗的PTCI患者80例，采用随机数字表法分为A组40例与B组40例。A组患者实施患侧腺叶+峡部切除+同侧中央区淋巴结清扫治疗，B组患者实施甲状腺全切术+同侧中央区淋巴结清扫治疗。比较两组手术、术后情况，并发症、甲状旁腺功能减退发生情况以及术前和术后3 d血清Tg水平。结果:A组PTCI患者手术时间为（78.95±13.52）min，短于B组的（104.23±27.38）min，PTCI患者术中出血量为（52.32±6.59）mL，少于B组的（75.41±9.98）mL（n t=-5.23、-12.21，均n P 0.05）。A组术后并发症发生率（10.00%）少于B组（30.00%）（χ n 2=5.00，n P < 0.05）。A组PTCI患者甲状旁腺功能减退发生率（7.50%）低于B组（27.50%）（χ n 2=5.54，n P < 0.05）。A组患者术后3 d血清Tg为（0.82±0.17）μg/L，低于B组的（1.26±0.23）μg/L（n t=-9.73，n P < 0.05）。n 结论:患侧腺叶+峡部切除+同侧中央区淋巴结清扫治疗PTCI患者效果优于甲状腺全切术+同侧中央区淋巴结清扫术，对甲状旁腺功能影响小，且可降低Tg水平，具备显著创新性和科学性。“,”Objective:To investigate the therapeutic effects of different surgical methods on papillary thyroid carcinoma of the isthmus (PTCI) and their effects on parathyroid function and thyroglobulin.Methods:Eighty patients with PTCI who underwent treatment in Zhejiang Xin\'an International Hospital from January 2016 to January 2021 were included in this study. They were randomly allocated to undergo ipsilateral lobectomy with removal of the isthmus combined with ipsilateral central neck lymph node dissection (group A, n n = 40) or total thyroidectomy combined with ipsilateral central neck lymph node dissection (group B, n n = 40). We compared intraoperative and postoperative conditions, complications, and hypoparathyroidism between the two groups. We also compared serum thyroglobulin level measured before and 3 days after surgery between the two groups.n Results:Operative time was significantly shorter in group A than in group B [(78.95 ± 13.52) minutes n vs. (104.23 ± 27.38) minutes, n t = -5.23, n P < 0.05]. Intraoperative blood loss was significantly less in group A than in group B [(52.32 ± 6.59) mL n vs. (75.41 ± 9.98) mL, n t = -12.21, n P 0.05). The incidence of complications was significantly lower in group A than in group B (10.00% n vs. 30.00%, n χ2 = 5.00, n P < 0.05). The incidence of hypoparathyroidism was significantly lower in group A than in group B (7.50% n vs. 27.50%, n χ2 = 5.54, n P < 0.05). At 3 days after surgery, serum thyroglobulin level was significantly lower in group A than in group B [(0.82 ± 0.17) μg/L n vs. (1.26 ± 0.23) μg/L, n t = -9.73, n P < 0.05].n Conclusion:Ipsilateral lobectomy with removal of the isthmus combined with ipsilateral central neck lymph node dissection is more effective on PTCI than total thyroidectomy combined with ipsilateral central neck lymph node dissection. The former has little effect on parathyroid function and can reduce serum thyroglobulin level. The study is highly innovative and scientific.