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目的:研究左卡尼汀在预防紫杉醇周围神经毒性中的应用效果;方法:选择2014年1月~2016年12月入住我院以细胞学或(和)病理学检查确诊为恶性肿瘤并行紫杉醇治疗的患者98例,按照随机数字表法分成左卡尼汀组(n=49)与对照组(n=49),左卡尼汀组给予左卡尼汀预防紫杉醇周围神经毒性,对照组未使用药物预防紫杉醇周围神经毒性。观察2组患者治疗期间周围神经毒性发生情况、发生时间以及疲劳分级等指标;结果:左卡尼汀组紫杉醇周围神经毒性0级发生率显著低于对照组,各等级紫杉醇周围神经毒性差异有统计学意义(p<0.05)。左卡尼汀组紫杉醇周围神经毒性发生率(8.16%)低于对照组(46.94%),差异有统计学意义(p<0.05)。左卡尼汀组疲劳分级评分低于对照组,紫杉醇周围神经毒性发生时间小于对照组,差异均有统计学意义(p<0.05);结论:左卡尼汀应用于紫杉醇周围神经毒性的预防可延长毒性发作时间,降低发生率,改善患者疲劳状况,值得临床应用。
To study the effect of levocarnitine in preventing peripheral neurotoxicity of paclitaxel.Methods: Choose January 2014 ~ December 2016 admitted to our hospital with cytology or (and) pathology diagnosed as malignant tumor concurrent paclitaxel treatment Of 98 patients were divided into levocarnitine group (n = 49) and control group (n = 49) according to random number table. L-carnitine group was given L-carnitine to prevent peripheral neurotoxicity of paclitaxel, and the control group was not used Drugs prevent paclitaxel peripheral neurotoxicity. The incidence of neurotoxicity, time of occurrence and the grade of fatigue were observed in the two groups of patients during treatment. Results: The incidence of peripheral neurotoxicity 0 in levocarnitine group was significantly lower than that of the control group, there were statistical differences in the peripheral neurotoxicity of paclitaxel Significance (p <0.05). The incidence of peripheral neurotoxicity of paclitaxel in levocarnitine group (8.16%) was lower than that in control group (46.94%), the difference was statistically significant (p <0.05). The fatigue score of levocarnitine group was lower than that of the control group, and the peripheral neurotoxicity of paclitaxel was less than that of the control group (p <0.05). Conclusion: L-carnitine can be used in the prevention of peripheral neurotoxicity of paclitaxel To extend the time of onset of toxicity, reduce the incidence and improve the patient’s fatigue status, it is worth clinical application.