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合成了γ 硫脲基丙基锗倍半硫化物 ,进行了99Tcm的标记 ,在配体量为 0 5mg,SnCl2 量为 0 .1mg ,pH =8.0 ,反应温度为 2 0℃ ,反应时间为 2 0min时 ,标记率可达 84 2 %。配合物在小鼠体内的生物分布实验结果表明 ,配合物主要浓集在肺中 ,其次是肝脏。在标记物质量浓度为 5 0 μg/mL时 ,测得它对KB(人鼻咽癌 ) ,HCT(人结肠癌 )和Bel(人肝癌 )细胞的抑制率分别为 69 0 % ,76 9% ,4 4 7%。
Γ thioureasopropylgermanium sesquisulfide was synthesized and labeled with 99Tcm. When the amount of ligand was 0 5mg, the amount of SnCl2 was 0.1mg, the pH was 8.0, the reaction temperature was 20 ℃ and the reaction time was 2 At 0 min, the labeling rate can reach 84 2%. Biodistribution experiments of the complexes in mice showed that the complexes mainly concentrated in the lungs, followed by the liver. At the concentration of 50 μg / mL, the inhibitory rates of the marker against KB (human nasopharyngeal carcinoma), HCT (human colon carcinoma) and Bel (human hepatocellular carcinoma) cells were 69 0%, 76 9% , 4 4 7%.