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Objective: Acute mountain sickness（AMS） is a common condition in individuals who ascend to altitudes over 2 500 m. There is no measurements that can reliably predict or diagnose this condition. We therefore determined whether pulse oximetry data are associated with the development of AMS and can help diagnose AMS. Methods: We studied 58 young male undergraduates who traveled from Chongqing（300 m） to Lhasa（3 658 m） by train. We collected data on the ascent profiles and AMS symptoms based on the Lake Louise Score（LLS）. The resting arterial oxygen saturation（R-Sp O2） and pulse rate were then measured using finger pulse oximetry. Results: In Golmud（2 800 m） and Tanggula（5 200 m）, R-SpO2 was significantly lower in the AMS group than in the group without AMS（P<0.05）. However, upon arrival in Lhasa（3 658 m）, the R-SpO2 was higher in the AMS group than in the non-AMS group（P<0.05）. In Tanggula, the change in the SpO2（CR-SpO2） in the AMS group was higher than that in the non-AMS group（P<0.05）. But in Lhasa, the CR-SpO2 in the AMS group was lower than that in the non-AMS group（P<0.05）. We also monitored heart rate（HR） throughout the study. In Xining（2 200 m） and Golmud, the HRs in the AMS group were higher than those in the non-AMS group. However, the HRs in the AMS group were lower than those in the non-AMS group in Tanggula and Lhasa. Conclusion: Based on the results of this study, the R-SpO2 graph was not consistent. We can thus conclude that the utility of SpO2 remains limited in the diagnosis of AMS. The results suggest that using pulse oximetry to diagnose AMS is not valuable in people ascending to Lhasa on the Qinghai-Tibet train.