SIRT1是依赖烟酰胺腺嘌呤二核苷酸(NAD+)的脱乙酰基酶,在低等动物中延长寿命,预防与年龄相关的疾病,包括代谢紊乱。激活SIRT1能增强线粒体的功能、氧化代谢和抵消肥胖。白黎芦醇是非黄酮类多酚类,属于对苯代乙烯组,是一些植物为了应对伤害和真菌攻击自然产生的。因此,白黎芦醇激活SIRT1对与年龄相关的疾病和生理代谢有重要的意义。 SIRT1 is a deacetylase that relies on nicotinamide adenine dinucleotide (NAD +) to prolong life in lower animals and prevent age-related diseases, including metabolic disorders. Activation of SIRT1 enhances mitochondrial function, oxidative metabolism and counteracting obesity. Resveratrol is a non-flavonoid polyphenols belonging to the para-vinylidene group that some plants naturally produce in response to injury and fungal attack. Therefore, resveratrol-activated SIRT1 has important implications for age-related disease and physiologic metabolism.