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目的 :观察铝碳酸镁对实验性大鼠胆汁反流性胃炎的治疗效果和对胆汁反流性胃炎患者的临床治疗效果。方法 :实验研究采用纵形切开大鼠胃幽门括约肌 ,制造胆汁反流性胃炎的实验模型并分组喂饲铝碳酸镁或硫糖铝 0 5g·d-1。 2wk或 4wk后取鼠全胃分送病理光镜与电镜检查。临床研究以胃镜下诊断为胆汁反流性胃炎的患者 ,随机接受铝碳酸镁或硫糖铝治疗 ,并逐日记录临床症状 ,其中治疗组有 30例于治疗 2wk后作胃镜复查。结果 :临床观察见铝碳酸镁治疗胆汁反流性胃炎的1wk显效率达 42 36 % ,总有效率为 89 6 5 % ;2wk的治疗显效率达 70 5 7% ,总有效率为 10 0 % ;铝碳酸镁的 1wk疗效与硫糖铝2wk疗效相似 ,明显优于硫糖铝对照组 (P <0 0 1) ;胃镜复查见胆汁反流和胃黏膜糜烂均有明显的好转。实验大鼠的病理光镜与电镜检查结果也见铝碳酸镁的疗效优于硫糖铝对照组。结论 :铝碳酸镁是治疗胆汁反流性胃炎的有效药物
Objective: To observe the therapeutic effect of hydrotalcite on bile reflux gastritis in rats and its clinical effect on patients with bile reflux gastritis. METHODS: The experimental study was conducted by longitudinal incision of the gastric pyloric sphincter to establish experimental models of bile reflux gastritis and fed with 0 5 g · d-1 of aluminum magnesium carbonate or sucralfate. After 2wk or 4wk mice take the whole stomach to send pathological light microscopy and electron microscopy. Clinical studies Gastric endoscopy diagnosis of bile reflux gastritis patients were randomized to receive magnesium aluminum carbonate or sucralfate, and clinical symptoms were recorded daily, of which 30 patients in the treatment group were treated for gastroscopy after 2 weeks. Results: Clinical observation showed that once a week, the effective rate of aluminum magnesium carbonate for treating bile reflux gastritis was 42 36%, the total effective rate was 89 65%; the effective rate of 2 wk was 70 57% and the total effective rate was 100% ; 1wk magnesium aluminum carbonate and sucralfate 2wk curative effect was significantly better than the sucralfate control group (P <0.01); gastroscopy showed bile reflux and gastric mucosal erosion were significantly improved. Pathological light microscopy and electron microscopy in experimental rats also showed that the therapeutic effect of magnesium aluminum carbonate was better than that of sucralfate control group. Conclusion: Magnesium aluminum carbonate is an effective drug for the treatment of bile reflux gastritis