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目的:观察冠状动脉慢血流(SCF)与血清脂联素(ANP)、高敏C反应蛋白(hs-CRP)水平之间的相关性。方法:选择行冠状动脉造影(CAG)显示冠状动脉无明显病变的患者70例,通过校正TIMI血流计帧法(cTFC)计算各支冠状动脉的血流帧数。冠状动脉血流平均帧数≥27定义为SCF,将患者分为SCF组(35例)和对照组(35例)。检测ANP和hs-CRP水平。结果:SCF组血清的APN水平低于对照组[(4.88±0.34)μg/ml∶(7.34±0.48)μg/ml,P<0.05],而其血清hs-CRP水平高于对照组[(2.13±1.07)μg/ml∶(1.29±0.69)μg/ml,P<0.05],Logistic回归分析表明hs-CRP是影响SCF的危险因素(OR=2.44,P=0.04),APN是SCF的保护性因素(OR=0.94,P=0.03)。结论:血清hs-CRP水平升高、APN水平降低与SCF相关,炎症反应在SCF发生的病理生理过程中起重要作用。
OBJECTIVE: To observe the correlation between slow coronary flow (SCF), serum adiponectin (ANP) and high sensitivity C-reactive protein (hs-CRP) levels. Methods: Seventy patients with coronary artery disease underwent coronary angiography (CAG) were selected. The blood flow frames of each coronary artery were calculated by calibrating TIMI flowmeter frame method (cTFC). The average number of coronary blood flow ≥ 27 was defined as SCF, the patients were divided into SCF group (35 cases) and control group (35 cases). ANP and hs-CRP levels were measured. Results: The serum APN level in SCF group was significantly lower than that in control group [(4.88 ± 0.34) μg / ml vs (7.34 ± 0.48) μg / ml, P <0.05] Logistic regression analysis showed that hs-CRP was the risk factor of SCF (OR = 2.44, P = 0.04), and APN was the protective factor of SCF (± 1.07) μg / ml: (1.29 ± 0.69) μg / Factors (OR = 0.94, P = 0.03). CONCLUSIONS: Serum hs-CRP level is elevated and APN level is decreased correlated with SCF. Inflammatory reaction plays an important role in the pathophysiological process of SCF.