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目的比较组成成分相近而比表面积与孔径不同的介孔材料和微孔材料的止血性能和放热反应规律,为以介孔材料为载体研发新型急救止血剂奠定基础。方法将15只雄性家猪随机分为3组(A组、B组、C组),分别建立猪股动脉致命性出血模型,A组应用介孔材料HW止血,B组应用微孔材料ZSM-5止血(阳性对照),C组应用标准纱布止血(阴性对照)。比较3组材料的止血性能以及放热反应对组织的影响。结果 A和B组止血时间分别为(49.50±3.27)s和(59.50±2.42)s(P<0.05),C组应用标准纱布止血失败;A、B、C各组局部最高温度分别为(42.0±1.58)、(46.4±1.14)和(36.8±0.84)℃,各组间差异均有统计学意义(P<0.05);组织学检查发现A组应用介孔材料HW的放热反应对组织造成的损伤轻于B组微孔材料ZSM-5。结论介孔材料HW比微孔材料ZSM-5具有更加快速的止血性能和更轻的放热反应,有望成为新一代急救止血剂研究载体。
Objective To compare the hemostatic properties and exothermic reaction of mesoporous materials and microporous materials with similar composition and different specific surface area and pore size, and lay a foundation for the development of new emergency hemostatic agents based on mesoporous materials. Methods Fifteen male domestic pigs were randomly divided into three groups (group A, group B, group C). The model of fatal hemorrhage was established respectively in group A and group B. Mesothelioma HW was used to stop bleeding. Group B was treated with microporous material ZSM-5 Hemostasis (positive control), C group standard gauze hemostasis (negative control). The hemostatic properties and the effects of exothermic reaction on the tissues of the three groups were compared. Results The bleeding time in group A and group B was (49.50 ± 3.27) s and (59.50 ± 2.42) s respectively (P <0.05), and the hemostatic failure of standard gauze in group C was failed. The maximum local temperatures in groups A, B and C were ± 1.58), (46.4 ± 1.14) and (36.8 ± 0.84) ℃, respectively, and there was significant difference among the groups (P <0.05). The histological examination revealed that the exothermic reaction of HW Less damage than Group B microporous material ZSM-5. Conclusion The mesoporous material HW has faster hemostatic performance and lighter exothermic reaction than the microporous material ZSM-5, and is expected to be a new generation of rescue hemostatic agent research carrier.