特发性ACTH缺乏的病因至今仍然不清楚,然而ACTH缺乏有时与几种自身免疫性疾病有关。因此自身免疫机制可能在其发病机理中发挥作用。有关肌萎缩侧索硬化(ALS)的免疫和内分泌功能障碍已有报道。作者报告一例伴发ACTH缺乏的ALS。 患者男性,70岁。全身疲乏、手肌无力1年,双腿无力近2月,近期发现手肌萎缩而就诊。无嗜酒、毒物接触或皮质类固醇治疗史。无ALS或其他神经疾病的家族史。查体:普通体检未发现异常。神经系统 The etiology of idiopathic ACTH deficiency remains unclear, yet ACTH deficiency is sometimes associated with several autoimmune diseases. Therefore, autoimmune mechanisms may play a role in its pathogenesis. Immunity and endocrine dysfunction of amyotrophic lateral sclerosis (ALS) have been reported. The authors report an ALS with ACTH deficiency. Male patient, 70 years old. Whole body fatigue, hand muscle weakness 1 year, weak legs nearly 2 months, recently found hand muscle atrophy and treatment. No alcohol, poison contact or corticosteroid therapy history. Family history without ALS or other neurological disorders. Physical examination: no physical examination found abnormalities. nervous system