大鼠、狗、猪以及各种灵长类动物是牙周病研究中常用的实验动物，但有关这些动物牙周组织的基础研究还不多。作者就现有资料对这些动物在牙周解剖、生理、组织、菌群组成及免疫等方面的特点及与人类相比的相似性和差异性进行了综述分析，并对这些实验动物的使用作了相应评价。作者认为有关牙周病实验动物的研究还需深入，以促使动物实验在牙周病研究中发挥更确实的作用。 Rats, dogs, pigs and various primates are common laboratory animals for periodontal disease research, but there are not many basic studies on the periodontal tissues of these animals. The authors reviewed the characteristics of these animals in terms of periodontal anatomy, physiology, tissue, flora and immunology, as well as the similarities and differences compared with human beings in the available data, and analyzed the use of these experimental animals The corresponding evaluation. The authors believe that the study of periodontal disease experimental animals needs further study to promote animal experiments in periodontal disease research to play a more real role.