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目的探讨急性脑梗死患者颈动脉硬化程度与血清半乳凝集素-3(Galectin-3)表达水平的关系及阿托伐他汀钙的干预作用。方法选取本院2013年12月~2015年12月急性脑梗死患者92例,抽签随机分为观察组与对照组,每组各46例,给予对照组患者基础治疗,观察组患者在对照组治疗基础上加用阿托伐他汀钙治疗,分析急性脑梗死患者颈动脉硬化程度与血清Galectin-3表达的关系,比较观察组与对照组患者治疗前后血脂、血清炎性因子、血清Galectin-3水平及欧洲卒中量表(ESS)、日常生活量表(BI)评分。结果急性脑梗死患者颈动脉硬化程度越严重,血清Galectin-3水平越高(P<0.05);治疗后观察组患者各项血脂、血清炎性因子及Galectin-3水平均较对照组显著较低(P<0.05);观察组治疗后ESS及BI评分较对照组显著增高(P<0.05)。结论血清Galectin-3水平与急性脑梗死患者颈动脉硬化程度有关,给予患者阿托伐他汀钙治疗能显著改善血脂水平,降低炎性因子水平,且生活质量得到提高。
Objective To investigate the relationship between the degree of carotid atherosclerosis and the expression of Galectin-3 in patients with acute cerebral infarction and the intervention of atorvastatin calcium. Methods Ninety-two patients with acute cerebral infarction from December 2013 to December 2015 in our hospital were enrolled. Randomly divided into observation group and control group with random sampling of 46 cases in each group. The patients in the control group were given basic treatment. The patients in the observation group were treated in the control group Based on the addition of atorvastatin calcium, the relationship between carotid atherosclerosis and serum Galectin-3 expression in patients with acute cerebral infarction was analyzed. The levels of serum lipids, serum inflammatory cytokines and serum Galectin-3 levels were compared between the two groups before and after treatment And the European Stroke Scale (ESS), daily life scale (BI) score. Results The severity of carotid atherosclerosis was more severe in patients with acute cerebral infarction, and the serum Galectin-3 level was higher (P <0.05). After treatment, the levels of serum lipids, serum inflammatory cytokines and Galectin-3 in the observation group were significantly lower than those in the control group (P <0.05). The scores of ESS and BI in the observation group were significantly higher than those in the control group (P <0.05). Conclusions Serum Galectin-3 levels are related to the degree of carotid atherosclerosis in patients with acute cerebral infarction. Calcium treatment with atorvastatin can significantly improve the blood lipid level, decrease the level of inflammatory cytokines, and improve the quality of life.