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目的了解嗜麦芽寡氧单胞菌医院感染的临床分布及其耐药性,为临床合理使用抗菌药物提供依据。方法用细菌分离鉴定和药敏试验方法,对某医院住院感染患者标本中病原菌及其耐药性进行检测。结果该医院在2010-2011年从住院感染患者标本中共分离出嗜麦芽寡氧假单胞菌331株,分离率居前3位的临床科室依次为重症监护病房(ICU)、呼吸内科和神经内科,分离率依次为41.2%、29.7%和8.6%。临床标本中以呼吸道标本分离率最高,占83.4%;其次是血液标本,占10.3%。临床分离的嗜麦芽寡氧假单胞菌对复方新诺明、左旋氧氟沙星和头孢哌酮/舒巴坦比较敏感,但对多数抗菌药物的耐药率均较高。结论嗜麦芽寡氧假单胞菌感染患者主要集中在ICU和呼吸内科,以呼吸道感染居多,对临床常用抗菌药物普遍耐药。
Objective To understand the clinical distribution and drug resistance of Stenotrophomonas maltophilia nosocomial infection and provide basis for rational use of antimicrobial agents in clinic. Methods Bacterial isolation and identification and drug susceptibility testing methods were used to detect the pathogenic bacteria and their drug resistance in the inpatients of a hospital. Results A total of 331 strains of Pseudomonas maltophilia were isolated from hospitalized patients in 2010-2011. The top three clinical departments were ICU, respiratory medicine and neurology The separation rates were 41.2%, 29.7% and 8.6%, respectively. Respiratory specimens in clinical specimens isolated the highest rate, accounting for 83.4%; followed by blood specimens, accounting for 10.3%. The clinically isolated Pseudomonas aeruginosa is more sensitive to the combination of cotrimoxazole, levofloxacin and cefoperazone / sulbactam, but has a higher rate of resistance to most antibiotics. Conclusions Patients with Stenotrophomonas maltophilia are mainly concentrated in the ICU and respiratory medicine. Most of them are respiratory infections, and are generally resistant to commonly used antimicrobial agents.