In order to improve the transmission rate of the compression system,a real-time video lossy compression system based on multiple ADV212 is proposed and achieved. Considering the CMOS video format and the working principle of ADV212,a Custom-specific mode is used for various video formats firstly. The data can be cached through the FPGA internal RAM and SDRAM Ping-Pong operation. And the working efficiency is greatly promoted. Secondly,this method can realize direct code stream transmission or do it after storage. Through the error correcting coding,the correction ability of the flash memory is highly improved. Lastly,the compression and de-compression circuit boards are involved to specify the performance of the method. The results show that the compression system has a real-time and stable performance. And the compression ratio can be changed arbitrarily by configuring the program. The compression system can be realized and the real-time performance is good with large amount of data. Considering the CMOS video format and the working principle of ADV212, a Custom-specific mode is used for various video formats first. The data can be cached through the FPGA internal RAM and SDRAM Ping-Pong operation. And the working efficiency is greatly promoted. Secondly, this method can realize direct code stream transmission or do it after storage. Through the error correcting coding Lastly, the compression and de-compression circuit boards are involved to specify the performance of the method. The results show that the compression system has a real-time and stable performance. And the compression ratio can be changed arbitrarily by configuring the program. The compression system can be realized and the real-time performance is good with large amount of data.