Objective: To explore the medication rules of Professor Ren Shunping treating spleen deficiency and qi stagnation syndrome of functional dyspepsia, so as to provide reference for clinical prevention and development of new drugs. Methods: The 144 Chinese herbal formulas considered as active prescribed by professor Ren Shunping for the first time treating the patients with spleen deficiency and qi stagnation syndrome of functional dyspepsia were collected, entered into TCM inheritance auxiliary platform (V2.5), and then mined by some data mining methods of the software, such as the association rules and unsupervised entropy hierarchical clustering. Results: This study involved 144 Chinese herbal formulas, including a total of 56 Chinese herbal medicines. Of these Chinese herbal medicines, the herbs of cold and warm nature, and pungent, bitter and sweet in flavors were used in a quite high frequency, all of which act on spleen, stomach, lungs, large intestine, liver and gallbladder meridians. One core Chinese herbal formula was excavated, composed of patchouli, perilla stem, radix bupleuri, scutellaria, ginger pinellia, codonopsispilosula, magnolia bark, tangerine peel, large-headed atractylodes, immature bitter orange, wood incense, fructus amomi, inula britannica chinensis, ginger, medicated leaven, fried rice and fried malt based on the association rules. And a total of 17 groups of core used drugs and 2 groups of new Chinese herbal formulas undiscovered were mined based on unsupervised entropy hierarchical clustering. Conclusion: In treating spleen deficiency and qi stagnation syndrome of functional dyspepsia, professor Ren is good at treating spleen deficiency and qi stagnation syndrome of functional dyspepsia from the perspective of “tong jiang”, using the “five-in-one” strategy of strengthening the spleen, evacuating the liver, coming down qi from the stomach, dispersing lung, and bowel-reflexing to treat patients as a whole. And the herbal medicines were light in dose, lovely and mild in nature for the formulars. At the same time, he paid attention to the combination of syndromes and symptoms, and flexible arbitration.