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目的：探讨综合干预措施对降低重症监护病房（ICU）多重耐药菌（MDRO）医院感染发病率的作用。方法选取某院6个成人 ICU 2014年1—12月收治的重症患者，2014年1—6月入院的患者作为对照组（不采取特殊干预措施），2014年7—12月入院的患者作为综合干预组（采取 MDRO 防控综合干预措施），比较两组患者 MDRO医院感染发病率。结果综合干预组收治的1030例患者中，391例检出 MDRO，发生 MDRO 医院感染105例，医院感染日发病率为7．63‰（105／13753）；对照组收治的1230例患者中，596例检出 MDRO，发生 MDRO 医院感染133例，医院感染日发病率为27．12‰（133／4905），综合干预组医院感染日发病率低于对照组，差异有统计学意义[RR及95％CI 为0．28（0．22～0．37），P ＜0．001]。结论综合干预措施可有效降低 ICU MDRO 医院感染发病率。“,”Objective To evaluate the effectiveness of comprehensive intervention measures in reducing the inci-dences of multidrug-resistant organism (MDRO )healthcare-associated infection (HAI )in intensive care units (ICUs).Methods Patients admitted to 6 adult ICUs between January and December 2014 were chosen,and divided into two groups,patients admitted to ICUs between January and June 2014 (without taking special intervention measures)were as control group,between July and December 2014 (taking comprehensive MORO prevention and control measures)were as comprehensive intervention group.Incidences of MDRO HAI of two groups were com-pared.Results Of 1 030 patients in comprehensive intervention group,391 were detected MDROs,105 developed MORO HAI,incidence of HAI was 7.63/1 000 patient-days(105/13 753);of 1 230 patients in control group,596 were detected MDROs,133 developed MORO HAI,incidence of HAI was 27.12/1 000 patient-days(133/4 905), incidence of HAI in comprehensive intervention group was significantly lower than control group(RR,0.28[95%CI , 0.22-0.37],P <0.001 ).Conclusion Comprehensive intervention measures can effectively reduce the incidence of MORO HAI in ICUs.