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目的了解余姚市现阶段手足口号病病原学特征,为防控提供科学依据。方法对余姚市三家医院2010年3-12月临床诊断病例采集大便或咽拭子,进行荧光定量RT-PCR检测,用描述流行病学等方法对确诊病例进行流行病学特征分析。结果 1 324例临床诊断病例中1 096例检出肠道病毒核酸阳性,阳性率82.78%,其中EV71阳性率37.99%,CoxA16阳性率为25.15%,病例主要集中在5岁以下儿童,占80.51%,住院病人EV71阳性率高达55.58%。粪便EV71阳性率明显高于咽拭子。结论余姚市手足口病病原学以EV71和CoxA16为主,EV71引起的手足口病情较重,粪便应作为手足口病监测的主要采集标本。
Objective To understand the etiological characteristics of hand, foot and mouth disease in Yuyao City at this stage and provide a scientific basis for prevention and control. Methods The stools or throat swabs were collected from three clinically diagnosed cases in three hospitals of Yuyao City from March to December in 2010. Fluorescent quantitative RT-PCR was used to detect the epidemiological characteristics of the confirmed cases. Results Of 1 324 cases, 1 096 cases of enterovirus positive were detected, the positive rate was 82.78%. The positive rate of EV71 was 37.99% and the positive rate of CoxA16 was 25.15%. The cases were mainly concentrated in children under 5 years old accounting for 80.51% , EV71 positive rate of inpatients as high as 55.58%. EV71 stool positive rate was significantly higher than throat swab. Conclusion The etiology of hand-foot-mouth disease in Yuyao is mainly EV71 and CoxA16, EV71-induced hand-foot-mouth disease is more serious and faeces should be the main collection specimen for hand-foot-mouth disease surveillance.