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引言噻嗪类利尿剂及β-肾上腺素能阻滞剂是当今最广泛应用的抗高血压药物;它们同样有降压作用。然而噻嗪类利尿剂有诱发糖尿病及损害糖耐量的副作用;且能引起潜在的低钾血症及体钾减少的危害;并增加血清尿酸及痛风的危险。1976年 Lewis 等的资料表明长期(6年)用噻嗪类利尿剂治疗乃是糖尿病的病因。我们对轻、中度高血压2年随机试验将苯氟甲噻嗪(Bendroflumethiaz-ide)与心得安比较,而不能同意这个断定,从此我们继续随访。本文报告了随机选择并均等的两组(n=53)中年男性轻、中度高血压患者用苯氟甲噻嗪及心得安治疗6年期间所见的抗高血压效果及代射变化。
Introduction Thiazide diuretics and β-adrenergic blockers are the most widely used antihypertensive drugs of the day; they also have antihypertensive effects. However, thiazide diuretics have side effects of inducing diabetes and impaired glucose tolerance; and can cause the potential hypokalemia and body potassium reduction hazards; and increase the risk of serum uric acid and gout. In 1976, Lewis and other data show that long-term (6 years) with thiazide diuretics is the cause of diabetes. We compared mild and moderate hypertension with 2-year randomized trial of bendroflumethiazide and propranolol, and could not agree with this assertion, since then we continue to follow-up. This article reports on the antihypertensive effects and oncologue changes seen during the 6-year period between the two groups (n = 53) of middle-aged and moderate-intensity hypertensive patients randomly selected and equalized by flubenzothiazide and propranolol.