大剂量化疗是指在短期内应用大剂量药物的治疗方法,又称加强化疗(Intensive che-motherapy)。尽管联合化疗改善了小细胞肺癌病人的缓解率,但总的来说,疗效很不理想。局限性病变在确诊之后只有20%左右能存活2年以上,仅占全部小细胞肺癌病人的5%。鉴于这种状况,不少学者探索采用大剂量化疗治疗小细胞肺癌,并加自体骨髓移植 High-dose chemotherapy refers to the treatment of large-dose drugs in the short term, also known as Intensive che-motherapy. Although combined chemotherapy improved the response rate of patients with small cell lung cancer, the overall effect was not ideal. Only 20% of localized lesions can survive for more than 2 years after diagnosis, accounting for only 5% of all patients with small cell lung cancer. In view of this situation, many scholars have explored the use of high-dose chemotherapy for small cell lung cancer and autologous bone marrow transplantation.