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目的:观察栀豉汤对更年期综合征出现的以植物神经功能紊乱为主的证候的调节作用,探讨本品对动物神经系统的调节作用。方法:以小鼠自主活动、睡眠时间和小鼠足趾出汗模型试验,观察口服栀豉汤400～800 mg·kg-1后对模型动物自主活动、睡眠时间及对汗腺分泌的影响。结果:本品能明显减少小鼠的自发活动,延长其睡眠时间,减少汗腺分泌。结论:栀豉汤400～800 mg·kg-1口服后,对小鼠神经系统有明显的调节作用,并有一定的量效关系。
Objective: To observe the effect of Zhizhitang on the syndromes of autonomic dysfunction in climacteric syndrome and to explore the regulatory effect of this product on the nervous system of animals. Methods: The spontaneous activity in mice, sleep time and mouse toe sweating model test to observe the effects of oral Zhi Zhi Tang 400 ~ 800 mg · kg-1 on the model animals, spontaneous activity, sleep time and secretion of sweat glands. Results: This product can significantly reduce the spontaneous activity of mice to extend their sleep time, reduce sweat gland secretion. Conclusion: Zhi Zhi Decoction 400 ~ 800 mg · kg-1 oral administration of the nervous system in mice have a significant role in the regulation, and have a certain dose-effect relationship.