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选择性醛固酮过少症临床上表现为与肾功能不全程度不相平行的高钾血症及钠耗损。根据血浆醛固酮水平低、尿中醛固酮排出减少以及在注入促皮质素(ACTH)后可的松呈正常分泌反应而确诊。常见原因包括各种病因所致低肾素血症、遗传性合成醛固酮的酶缺陷以及药物(肝素、多巴胺)所致醛固酮合成障碍。作者报道95例慢性肾炎患者在以2～4万 U/d 肝素治疗过程中6例出现选择性醛固酮过少症。6例患者平均年龄30.8±3.1岁,病程3.5～10年,均有早期肾功能不全(血 Cr158～316μmol/L),肾活检示纤
Secretion of aldosteronism is clinically manifest as hyperkalemia and sodium depletion that are not parallel to the extent of renal insufficiency. According to the low level of plasma aldosterone, decreased urinary aldosterone excretion and injection of corticotropin (ACTH) cortisone normal secretion reaction was confirmed. Common causes include low encephalinmia due to a variety of etiologies, enzymatic defects in hereditary aldosterone synthesis, and aldosterone synthesis disorders caused by drugs (heparin, dopamine). The authors report that 95 patients with chronic nephritis showed selective hypoaldoxemia in 6 patients during treatment with 2 to 40,000 U / d heparin. Six patients had an average age of 30.8 ± 3.1 years and a duration of 3.5 to 10 years. All of them had early renal insufficiency (blood Cr158 ~ 316μmol / L), renal biopsy