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压力性尿失禁(SUI)是成年女性常见的泌尿系统疾病,给患者生活、工作和社会活动带来极大的影响。目前悬吊带术治疗SUI较成熟,微创简便,疗效确切,但可能出现并发症或者疾病复发。尿道周围注射填充剂,如牛胶原蛋白,远期效果不理想。干细胞是近年来研究的热点,有学者已尝试用其治疗SUI,特别是在大鼠SUI模型中研究较多,经尿道周围注射干细胞,如骨髓来源干细胞,肌肉来源干细胞和脂肪来源干细胞等,其可分化为平滑肌细胞等,提高大鼠尿道括约肌单位的功能,并促进神经细胞再生;注射的干细胞还可旁分泌多种因子,促进尿道组织再生,多种机制共同作用恢复尿道生理性的尿流控制能力。该治疗方法在临床开展较少,但仅有的数据也表明,在超声引导下经尿道周围注射干细胞能明显提高SUI患者的预后,改善排尿状况。
Stress urinary incontinence (SUI) is a common urinary system disease in adult women, which greatly affects the life, work and social activities of patients. At present, the treatment of SUI suspension strap more mature, minimally invasive and simple, the exact effect, but there may be complications or disease recurrence. Periurethral injection of fillers, such as bovine collagen, long-term effect is not satisfactory. Stem cells have been the hotspot of research in recent years. Some scholars have tried to treat SUI with them. Especially in rat SUI model, stem cells such as bone marrow-derived stem cells, muscle-derived stem cells and adipose-derived stem cells are injected around the urethra Can be differentiated into smooth muscle cells, etc., to improve rat urethral sphincter function and promote nerve cell regeneration; injected stem cells can also paracrine many factors to promote urethral tissue regeneration, a variety of mechanisms to restore urinary physiological urinary flow control ability. The treatment is less developed clinically, but the only data also show that the ultrasound-guided transurethral injection of stem cells can significantly improve the prognosis of SUI patients to improve urination.