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目的:观察应用丹参川芎嗪联合泼尼松治疗原发性肾病综合征的疗效。方法:160例肾病综合征病人随机分成两组,每组80例,试验组给予丹参川芎嗪联合泼尼松治疗,对照组单用泼尼松治疗,观察12周,观察治疗后两组疗效与不良反应,并于治疗后4,8和12周检查血清白蛋白,尿蛋白定量,肾小球滤过率等指标。结果:两组治疗12周后,24 h尿蛋白定量均下降,其中试验组在治疗后尿蛋白定量与对照组有显著性差异(P<0.05),而血清白蛋白与肾小球滤过率均有不同程度升高。试验组治疗有效率86%(69/80),对照组为74%(59/80),两组差异有统计学意义(P<0.05),且试验组药物副作用小于对照组。结论:丹参川芎嗪联合泼尼松能够有效缓解肾病综合征。
Objective: To observe the application of ligustrazine plus prednisone in the treatment of primary nephrotic syndrome. Methods: One hundred and sixty patients with nephrotic syndrome were randomly divided into two groups (n = 80 in each group). The experimental group was treated with ligustrazine and prednisone. The control group was treated with prednisone alone for 12 weeks. Adverse reactions, and at 4, 8 and 12 weeks after treatment, serum albumin, urine protein, glomerular filtration rate and other indicators. Results: After 12 weeks of treatment, urinary protein excretion of 24 h decreased, in which the urinary protein in the experimental group after treatment was significantly different from the control group (P <0.05), while serum albumin and glomerular filtration rate All have different degrees of increase. The effective rate of the experimental group was 86% (69/80) and that of the control group was 74% (59/80). The difference between the two groups was statistically significant (P <0.05). The side effects of the test group were less than those of the control group. Conclusion: Salviae miltiorrhizae combined with prednisone can effectively relieve nephrotic syndrome.