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为探讨偏头痛与甲硫氨酸脑啡肽（MEK）和β-内啡肽（β-EP）含量变化的关系，检测了30例偏头痛患者血浆及脑脊液MEK、β-EP在同一偏头痛患者不同时期的含量及21例健康正常人血浆MEK、β-EP的含量，做统计学处理。结果发现：偏头痛患者脑脊液中MEK、β-EP含量的变化与血浆的变化基本一致；偏头痛患者间歇期MEK浓度显著低于发作期（P＜0．001）及健康对照组（P＜0．001）；β-EP含量普遍降低，在无先兆性偏头痛（COM）组发作期明显低于间歇期（P＜0．05）；同时发现间歇期血浆β-EP含量在COM与健康组相似，在先兆性偏头痛（CLM）组则有较明显降低。结果表明：偏头痛患者存在鸦片类肽系统紊乱，MEK降低可导致偏头痛发作；β-EP含量减少可能是偏头痛发作的诱因之一，偏头痛发作与β-EP进一步降低有关。
To investigate the relationship between migraine and methionine enkephalin (MEK) and β-endorphin (β-EP) content, MEK and β-EP in plasma and cerebrospinal fluid of 30 patients with migraine were detected in the same migraine The content of MEK and β-EP in 21 patients with normal period were statistically analyzed. The results showed that the changes of MEK and β-EP in cerebrospinal fluid of migraine patients were basically the same as those in plasma. The MEK concentration in patients with migraine during intermission was significantly lower than that in patients with exacerbation (P <0.001) and healthy controls (P <0) (P <0.05). The β-EP content in intermittent period was significantly lower in the COM group than in the healthy group Similarly, there was a significant decrease in the CLM group. The results showed that there was disorder of opioid peptide system in migraine patients and the decrease of MEK could lead to the onset of migraine. The decrease of β-EP might be one of the causes of migraine, and the onset of migraine was related to the further decrease of β-EP.