目的观察杓型和非杓型高血压患者维生素D水平的差异。方法纳入200例原发性高血压患者,对每位患者进行24h动态血压监测(ABPM),根据夜间血压下降率将入选患者分为杓型组和非杓型组,每组均为100例患者,采用电化学发光法检测和比较两组患者血清25羟基维生素D[25(OH)D]水平的差异。结果非杓型组患者诊室血压高于杓型组[(146.4±6.1)/(92.9±3.1)比(143.7±7.0)/(91.5±3.8)mm Hg,P<0.05]。与杓型组比较,非杓型组高血压患者血清25(OH)D水平较低[(39.3±5.1)比(50.2±8.7)nmol/L,P<0.01]。Pearson相关分析显示,高血压患者血清25(OH)D水平与夜间收缩压和舒张压下降率呈正相关(分别r=0.547,P<0.01;r=0.533,P<0.01)。多元逐步Logistic回归分析结果显示,25(OH)D是非杓型高血压的影响因素(B值为-0.463,P<0.05)。结论非杓型高血压患者血清维生素D水平显著低于杓型高血压患者。 Objective To observe the differences of vitamin D levels between dipper and non-dipper hypertensive patients. Methods A total of 200 patients with essential hypertension were included in this study. The ambulatory blood pressure monitoring (ABPM) was performed on each patient for 24 hours. According to the rate of nocturnal decline in blood pressure, the patients were divided into dipper group and non-dipper group, 100 patients in each group . The differences of serum 25-hydroxyvitamin D [25 (OH) D] levels between the two groups were detected and compared by electrochemiluminescence. Results The blood pressure of the non-dipper group was higher than that of the dipper group [(146.4 ± 6.1) / (92.9 ± 3.1) vs (143.7 ± 7.0) / (91.5 ± 3.8) mm Hg, P <0.05]. Compared with the dipper group, the serum 25 (OH) D level in the non-dipper group was lower than that in the dipper group [(39.3 ± 5.1) vs (50.2 ± 8.7) nmol / L, P <0.01]. Pearson correlation analysis showed that serum 25 (OH) D level in patients with hypertension was positively correlated with nocturnal systolic and diastolic blood pressure drop rates (r = 0.547, P <0.01; r = 0.533, P <0.01, respectively). Multivariate Logistic regression analysis showed that 25 (OH) D was the influencing factor of non-dipper hypertension (B value -0.463, P <0.05). Conclusions Serum vitamin D levels in non-dipper hypertensive patients were significantly lower than those in dipper hypertensive patients.