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10——羟基喜树碱是从喜树中分得的一种微量生物碱。上海药物研究所等单位对羟基喜树碱的研究作了大量工作,显示其对多种动物肿瘤有明显的抑制作用。羟基喜树碱抗瘤作用比喜树碱强,毒性较喜树碱小,临床迄今已用300余例,证明对肝、胃及头颈部肿瘤有一定的疗效。对原发性的肝癌,疗效尤为显著。现将有关实验研究及临床结果汇集如下:
10-Hydroxycamptothecin is a trace alkaloid that was isolated from Camptotheca acuminata. Shanghai Pharmaceutical Research Institute and other organizations have done a lot of work on the study of hydroxycamptothecin, showing that it has a significant inhibitory effect on a variety of animal tumors. Hydroxycamptothecine is more potent than camptothecin and less toxic than camptothecin. Up to now, more than 300 cases have been used clinically to prove that it has certain curative effect on liver, stomach and head and neck tumors. For primary liver cancer, the effect is particularly significant. The relevant experimental research and clinical results are now assembled as follows: