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:将 40例慢性乙型肝炎患者随机分为 A、B两组 ,A组采用左旋咪唑涂布剂联合α- Ib干扰素治疗 ,B组采用健肝乐冲剂联合香菇多糖注射液。治疗 90 d后 ,AL T复常率 A、B两组分别为 85 %和 45 % ,差异非常显著 (P<0 .0 1)。HBVDNA、HBe Ag、抗 - HBc Ig M阴转率 A组依次为 75 .0 %、6 2 .5 %、81.8% ;B组依次为 2 6 .7%、13.3%、2 0 .2 % ,两组差异非常显著 (P<0 .0 1)。结果表明 ,采用左旋咪唑涂布剂联合α- Ib干扰素治疗慢性乙型肝炎有明显抑制病毒复制的作用。
: 40 patients with chronic hepatitis B were randomly divided into A, B two groups, A group with levamisole coating combined with α-1b interferon treatment, B group with Jiangan Le granules combined with lentinan injection. After 90 days of treatment, the ALT normalization rate was 85% in group A and 45% in group B, the difference was significant (P <0.01). The negative conversion rates of HBVDNA, HBe Ag and anti-HBc Ig M in group A were 75.0%, 62.5% and 81.8%, respectively; those in group B were 26.7%, 13.3% and 20.2% The difference between the two groups was significant (P <0.01). The results showed that the use of levamisole coating combined with α-1b interferon treatment of chronic hepatitis B significantly inhibited the role of viral replication.