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药物排泄主要是通过肾脏。当肾功能减退时,原形药物经肾脏的排泄率减少,使药物的半衰期延长,血药浓度升高。故肾功能减退的病人比肾功能正常的病人药物毒副反应的发生率高.为了使肾功能减退的病人既保持有效的血药浓度,又减少药物的毒副反应的发生,故对其给药方案必须进行调整。即调整给药间隔时间或调整给药剂量。一、调整给药间隔时间对肾功能减退的病人,若单次给药剂量不变,就需调整给药阖隔时间。其调整给药间隔时间公式:
Drug excretion is mainly through the kidneys. When renal dysfunction, prototype drugs by the renal excretion rate decreased, so that the half-life of drugs, plasma concentration increased. Therefore, patients with renal dysfunction than the normal renal function of patients with high incidence of drug toxicity in order to enable patients with renal dysfunction while maintaining effective plasma concentration, but also reduce the incidence of drug side effects, so to give Drug programs must be adjusted. That is, adjust the interval between administrations or adjust the dosage. First, adjust the interval between the administration of renal dysfunction in patients with a single dose, the need to adjust the administration interval. Adjust the interval time formula: