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将“脑啡肽酶”抑制剂 Thiorphan 或氨肽酶抑制剂 Bestatin 经慢性埋植套管注入家兔一侧状核内,观察到明显的镇痛作用,在1—4μg 范围内呈现明确的剂量-效应关系。该作用可为伏核内注射纳洛酮或甲啡肽抗体所完全翻转,亮啡肽抗体则无效。表明伏核内注射 Thior-Phan 或 Bestatn 所产生的镇痛效应主要是通过甲啡肽而完成的。伏核内注射微量 Thiorphan 或 Bestatin 使电针镇痛的后效应明显加强,并能增强吗啡的镇痛作用。表明电针和吗啡的镇痛效果至少有一部分是通过在伏核内释放出脑啡肽(特别是甲啡肽)而实现的。
The enkephalinase inhibitor Thiorphan or the aminopeptidase inhibitor Bestatin was injected into the lateral nucleus of a rabbit through a chronic implanting cannula. Obvious analgesic effect was observed and a definite dose was observed in the range of 1-4 μg - the relationship between effects. This effect can be completely reversed by the injection of naloxone or the methotrexate in the nucleus accumbens, whereas the leu-enkephalin antibody is ineffective. The results showed that the intramuscular injection of Thior-Phan or Bestatn analgesic effect is mainly through the completion of the methamidophos. Microinjection of Thiorphan or Bestatin into the nucleus accumbens markedly enhances the post-analgesic effect of EA and enhances the analgesic effect of morphine. Indicating that at least part of the analgesic effect of electroacupuncture and morphine is achieved by the release of enkephalin (especially, methotrexate) in the nucleus accumbens.