The transient flow mathematical model of arbitrary shaped heterogeneous reservoirs with impermeability barrier is proposed in this paper. In order to establish this model, the perturbation method is employed and the solution of model is expanded into a series in powers of perturbation parameter. By using the Boundary Element Method (BEM) and Duhamel principle, wellbore pressure with effects of skins and wellbore storage is obtained. The type curves are plotted and analyzed considering effects of heterogeneity, arbitrary shape and impermeable barriers. Finally, the results obtained by perturbation boundary element method is compared with the analytical solution and is available for the transient pressure analysis of arbitrary shaped reservoirs.