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大环内酯类抗生素广泛用于治疗呼吸道感染,但日益泛滥的大环内酯耐药菌正影响着公众的健康。为了解决这一问题,科研工作者对大环内酯类化合物进行了大量的结构修饰。综述近年来对红霉素衍生物C6位进行的结构改造及对其生物活性的影响。
Macrolide antibiotics are widely used in the treatment of respiratory infections, but the growing prevalence of macrolide-resistant bacteria is affecting public health. In order to solve this problem, researchers carried out a large number of structural modifications of macrolide compounds. This review summarizes the structural transformation of C6-derived erythromycin derivatives in recent years and their effects on their biological activity.