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用140只 SD 大鼠以酒精及去氧胆酸钠处理90天诱发实验性慢性胃炎。实验包括二部分,第一部分用60只大鼠研究胃炎冲剂的预防作用,其中20只大鼠单纯诱发胃炎作为模型组,其余40只在诱发过程中同时灌服胃炎冲剂,该部分还用10只正常大鼠作为对照组。第二部分用80只大鼠作治疗性研究,分设4组分别以生理盐水、胃炎冲剂及三九胃泰处理30天。实验结束时观察并比较胃粘膜的组织学变化。结果证明 SD 大鼠的实验性慢性胃炎的病理学特点与人类的相似;在本研究中发现胃炎冲剂对 SD 大鼠的慢性胃炎有肯定性的防治作用。
Experimental chronic gastritis was induced with 140 SD rats treated with alcohol and sodium deoxycholate for 90 days. The experiment included two parts. In the first part, 60 rats were used to study the preventive effect of gastritis granules. Twenty rats only induced gastritis as a model group, while the remaining 40 rats were administrated with gastritis at the same time during the induction process. Normal rats served as control groups. In the second part, 80 rats were used for therapeutic study. Four groups were treated with saline, gastritis and Sanjiuweitai for 30 days. At the end of the experiment, the histological changes in the gastric mucosa were observed and compared. The results demonstrated that the pathological features of experimental chronic gastritis in SD rats were similar to those of humans. In this study, it was found that Weiyan Granules had a positive preventive and therapeutic effect on chronic gastritis in SD rats.