尽管癫痫病人的许多痫性放电来自皮质,且对其研究也主要集中在皮质,但越来越多的证据表明,脑干有自身维持发作放电的功能,在全身性强直发作和传播中起着关键作用。本文复习近年来有关研究脑干机制的文献,着重讨论癫痫的脑干机制,包括解剖、生理、生化、病理及药物作用机制。 Although many epileptic patients have epileptic discharges from the cortex and their studies are mainly focused on the cortex, there is growing evidence that the brainstem has the function of sustaining episodic discharge itself and plays a role in generalized tonic attacks and transmission Key role. This review of the recent literature on the study of brain stem mechanism, focusing on the brain stem mechanism of epilepsy, including anatomy, physiology, biochemistry, pathology and drug action mechanism.