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目的考察“天癸一号方”治疗抗精神病药物引起的药源性闭经的临床作用。方法选择2015年1月~2016年2月本科收治的抗精神病药物所致药源性闭经的女性初治患者共96例,随机分为治疗组(48例)和对照组(48例)。对照组应用常规的抗精神病药物和常规治疗闭经的药物,而治疗组则在此基础上加用“天癸一号方”。治疗结束后对两组患者月经状况改善的临床疗效、内分泌调节情况和精神状况等进行研究及比较。结果治疗结束后,治疗组临床总有效率(89.6%)显著高于对照组(72.9%)(P<0.05);两组的泌乳素(PRL)在治疗后均有一定程度的下降,同时雌二醇(E2)、卵泡生成素(LH)等激素指标则出现上升的情况,差异均显著(P<0.05),而治疗组与对照组相比,治疗前后各激素指标的差值更大;在情绪指标上,两组的汉密尔顿焦虑量表(HAMA)得分差异不显著(P>0.05),而治疗组的汉密尔顿抑郁量表(HAMD)评分显著低于对照组(P<0.05)。结论在常规治疗的基础上加用“天癸一号方”可以有助于改善患者的内分泌状况,对于治疗抗精神病药物导致的药源性闭经具有更为良好的临床疗效。
Objective To investigate the clinical effect of drug-induced amenorrhea caused by anti-psychosis drug “Tian Decochang Fang”. Methods A total of 96 female patients with drug-induced amenorrhea induced by antipsychotics from January 2015 to February 2016 were randomly divided into treatment group (48 cases) and control group (48 cases). The control group used conventional antipsychotics and conventional amenorrhoeic drugs, while the treatment group added “Tiangui No.1” to the treatment group. After treatment, the clinical efficacy, endocrine regulation and mental status of two groups of patients to improve menstrual status were studied and compared. Results After treatment, the total effective rate (89.6%) in the treatment group was significantly higher than that in the control group (72.9%) (P <0.05). PRL in both groups decreased to a certain degree after treatment, There was a significant difference between the two groups (P <0.05), but there was a significant difference between the treatment group and the control group before and after treatment. There was no significant difference in HAMA scores between the two groups (P> 0.05), while the Hamilton Depression Rating Scale (HAMD) score of the treatment group was significantly lower than that of the control group (P <0.05). Conclusion The addition of “Tiangui Decoction” on the basis of routine treatment can help to improve the endocrine status of patients and has a better clinical efficacy for the treatment of drug-induced amenorrhea caused by antipsychotics.