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应用电热原子吸收光谱分析技术 (EAAS)对血浆、尿液、胆汁及各种组织中的总铂的含量进行了测定。研究表明 ,经合理的原子化程序设定后 ,尿液和胆汁可以不加处理直接进样 ,血浆用 0 .2 5 % Triton X- 10 0等量稀释 ,组织只采用简单快捷的均相酸消化法。本方法精密度 RSD<10 % ,回收率 87.40 %～ 110 .0 % ,在 0 .0 8～5 .0 0 μg/ml铂浓度范围线性关系良好 ,相关系数 r>0 .996 2 ,适合于铂类药物药代动力学的研究。
The content of total platinum in plasma, urine, bile and various tissues was determined by electrothermal atomic absorption spectrometry (EAAS). Studies have shown that urine and bile can be directly injected without any treatment after a reasonable set of atomization procedures have been set up. The plasma is diluted equally with 0.25% Triton X-100, and the tissue is prepared using only the simple and quick homogeneous acid Digestion. The method has the advantages of good RSD <10%, recovery of 87.40% ~ 110.0%, good linearity in the range of 0.08 ~ 5.0 0 μg / ml of platinum, the correlation coefficient r> 0.996 2, Pharmacokinetics of platinum drugs.