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目的:探讨多灶性脑血管母细胞瘤临床特点及其适宜的外科治疗方法。方法:回顾性分析9例经21次手术为病理证实的26枚多灶性脑血管母细胞瘤。结果:VHL患者产生多灶性脑血管母细胞瘤(45.4%)明显高于散发性脑血管母细胞瘤所产生的多灶病变(3.73%)。囊结节瘤18枚及实质性肿瘤8枚中,除1例实质性肿瘤与脑干粘连紧密而行次全切除外,余皆全切。手术后死亡1例,随访发现7例有肿瘤复发,复发间隔2～127个月,平均51个月。结论:MRI多轴位及增强扫描能清楚显示肿瘤及瘤结节,对囊结节瘤应避免手术探查遗漏,实质性肿瘤力争全切除。多灶病变易复发及产生新病灶而需要多次手术。
Objective: To explore the clinical features of multifocal hemangioblastoma and its suitable surgical treatment. Methods: Totally 26 multifocal hemangioblastomas confirmed by pathology were retrospectively analyzed in 9 cases. Results: Multifocal hemangioblastomas (45.4%) were significantly higher in VHL patients than in multifocal lesions (3.73%) due to sporadic hemangioblastomas. Bladder nodular tumor 18 and 8 substantive tumors, in addition to a case of solid tumor and brain stem adhesion and subtotal subtotal resection, I have all cut. One patient died after surgery. Follow-up was found in 7 patients with tumor recurrence interval of 2 to 127 months, an average of 51 months. Conclusion: MRI multi-axial and enhanced scanning can clearly show the tumor and tumor nodules, cystic nodules should avoid surgical exploration omission, and strive for total tumor resection. Multifocal lesions prone to recurrence and produce new lesions and require multiple surgeries.