论文部分内容阅读
目的探讨单纯接触温石棉与肺癌发病的关系。方法按照巢式病例对照的研究方法,从一个追踪了30年接触温石棉的男性固定队列中,收集所有的肺癌患者作为病例组,按1:4的配对比例在该队列中选取非癌症者作为对照组,配对因素为同性别、年龄相差<5岁、工龄相差<5年、吸烟情况一致。结果研究队列中收集到40例肺癌病例,发病水平高于全国平均水平[标化死亡比(SMR)= 1.77]。肺癌发病密度由高到低的工种分别是原料工(741.5/10万人年)、梳纺工(424.3/10万人年)、编织工(365.0/10万人年)、维修工(285.5/10万人年),与接触温石棉的浓度高低一致。与低浓度接触组比较,高浓度接触组发生肺癌的相对危险度(OR)为3.7,95%可信区间为2.30～8.16,差异有统计学意义(P<0.01)。结论单纯温石棉接触能增加工人肺癌发病的危险性。
Objective To investigate the relationship between simple exposure to chrysotile and lung cancer. Methods According to a nested case-control study, all patients with lung cancer were enrolled as male patients from a fixed cohort of men who were followed for 30 years with chrysotile, and non-cancer patients were enrolled in the cohort at a 1: 4 ratio In the control group, the matching factor was same sex, the difference of age was <5 years, the difference of working years was less than 5 years, and the smoking was the same. Results Forty cases of lung cancer were collected in the study cohort with a higher incidence than the national average [standardized mortality ratio (SMR) = 1.77]. The highest and lowest incidence of lung cancer were raw material workers (741.5 / 100,000 person-years), comb spinning workers (424.3 / 100,000 person-years), weaving workers (365.0 / 100,000 person-years) and maintenance workers 100,000 people), consistent with the level of chrysotile exposure. Compared with the low-concentration exposure group, the relative risk (OR) of high-concentration exposure group was 3.7 and the 95% confidence interval was 2.30-8.16, with significant difference (P <0.01). Conclusions Pure chrysotile asbestos exposure can increase the risk of lung cancer in workers.