论文部分内容阅读
目的探讨肝细胞癌(HCC)术后总生存(OS)相关的临床病理学参数。方法纳入HCC患者66例,随访根治性术后OS情况,平均随访时间(39.2±25.6)个月(2.6~73.3个月)。临床病理学参数与OS的相关性分析采用Log-rank检验、Kaplan-Meier曲线和多变量Cox风险比例模型。结果单因素分析结果显示,血清-L岩藻糖苷酶(AFU)水平、有无完整肿瘤包膜和TNM分期与OS呈显著性相关(均<0.05);多变量Cox回归分析显示,肝功能Child分级B级、无完整肿瘤包膜和TNM III期是HCC术后不良OS的独立预后因素。结论肿瘤包膜完整性以及TNM分期和肝功能Child分级是HCC术后OS的独立预后因素,肿瘤包膜完整性评估和预后指导意义应得到病理与临床医生的充分重视。
Objective To investigate the clinical pathological parameters related to overall survival (OS) after hepatocellular carcinoma (HCC). Methods Sixty-six patients with HCC were enrolled. Follow-up radical postoperative OS was performed. The average follow-up time was (39.2±25.6) months (2.6-73.3 months). The correlation between clinicopathological parameters and OS was analyzed by Log-rank test, Kaplan-Meier curve and multivariate Cox risk proportional model. Results Univariate analysis showed that the levels of serum-L fucosidase (AFU), presence or absence of intact tumor envelope, and TNM stage were significantly associated with OS (all <0.05). Multivariate Cox regression analysis showed that liver function was Child. Grade B, incomplete tumor capsule, and TNM III stage were independent prognostic factors for adverse OS after HCC. Conclusion Tumor envelope integrity, TNM staging and Child function grade of liver function are independent prognostic factors of OS after HCC. The assessment of tumor capsule integrity and the significance of prognosis should be fully valued by pathologists and clinicians.