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[目的]探讨三氧化二砷对鼻咽癌放射增敏作用。[方法]87例T1～4N0～1期鼻咽癌病人随机分为单纯放疗组(对照组)和三氧化二砷+放射治疗组(试验组),观察两组病人鼻咽肿瘤和颈部肿瘤消退情况,1、2年生存率及毒副反应。[结果]放射治疗40Gy时试验组和对照组的鼻咽肿瘤消退率分别为45.45%(20/44)和18.60%(8/43),差异有统计学意义(χ2=7.183,P=0.007)。两组的颈部肿瘤消退速度无统计学差异。40Gy时肿瘤消失组和残留组1、2年无病生存率分别为100%、90.9%和82.2%、69.3%,差异有统计学意义。试验组白细胞降低和恶心呕吐较对照组发生率高,但多为Ⅰ～Ⅱ度反应。其他毒副反应两组间差异无统计学意义。[结论]放疗联合三氧化二砷增敏使鼻咽肿瘤消退更快,且无严重毒副作用。
[Objective] To investigate the radiosensitization effect of arsenic trioxide on nasopharyngeal carcinoma. [Method] Eighty-seven patients with T1 ~ 4N0 ~ 1 NPC were randomly divided into radiotherapy group (control group) and arsenic trioxide + radiotherapy group (experimental group) to observe the regression of nasopharyngeal tumor and neck tumor in two groups of patients, 1, 2-year survival rate and side effects. [Results] The nasopharyngeal tumor regression rates of the experimental group and the control group were 45.45% (20/44) and 18.60% (8/43) respectively at 40 Gy of radiotherapy, the difference was statistically significant (χ2 = 7.183, P = 0.007) . There was no significant difference in the regression rate of neck tumors between the two groups. At 40 Gy, the 1-year and 2-year disease-free survival rates of tumor disappearance group and residual group were 100%, 90.9%, 82.2% and 69.3% respectively, with statistical significance. The experimental group, leukopenia and nausea and vomiting than the incidence of the control group, but mostly Ⅰ ~ Ⅱ degree response. Other toxicities between the two groups showed no significant difference. [Conclusion] Radiotherapy combined with arsenic trioxide sensitizes nasopharyngeal tumors to subside more quickly without serious side effects.