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合成了１８个Ｎ－苄氧羰基保护的４－取代氨基酸酰胺基－４－脱氧－４′－去甲基表鬼臼毒素衍生物。它们在体外试验中显示出良好的抗Ｌ１２１０白血病细胞（ＩＣ５０２．７×１０－１～４．０×１０－４ｍｇ／Ｌ）和ＫＢ细胞的活性，部分新化合物的抗Ｌ１２１０和ＫＢ细胞的活性超过依托泊甙［Ｅｔｏｐｏｓｉｄｅ，ＩＣ５０（Ｌ１２１０）１．０×１０－１ｍｇ／Ｌ］。
Eighteen N-benzyloxycarbonyl protected 4-substituted amino acid amido-4-deoxy-4’-demethylepipodophyllotoxin derivatives were synthesized. They showed good activity in anti-L1210 leukemia cells (IC50 2.7 × 10 -1 ~ 4.0 × 10 -4 mg / L) and KB cells in in vitro experiments, and some of the new compounds were more active against L1210 and KB cells Etoposide, IC50 (L1210) 1.0 × 10-1 mg / L].