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为了探讨丙戊酸钠缓释片（ＳＲ－ＶＰＡ）的定量脑电图效应，对１０例癫痫患者单剂量口服ＳＲ－ＶＰＡ前后的脑电图效应及血清浓度进行了动态研究，结果显示：随着血浓度的升高，枕区主频段绝对功率逐渐增加、β频段功率百分比逐淅降低；当浓度达峰值时，二者分别达最高和最低，尔后又分别随着血浓度的下降而呈降低和增加趋势。枕区主频段绝对功率与血浓度呈正相关，后头部β频段功率百分比与浓度呈负相关。
In order to investigate the quantitative electroencephalogram effect of sodium valproate sustained-release tablets (SR-VPA), the electroencephalogram effect and serum concentration of SR-VPA before and after single-dose oral administration of 10 epilepsy patients were studied. The results showed that With the increase of blood concentration, the absolute power of the main frequency band in the occipital region increased gradually and the power percentage in the β-frequency band decreased gradually. When the concentration peaked, the two reached the highest and the lowest, respectively, and then decreased as the blood concentration decreased And increase the trend. The absolute power of the main frequency band in the occipital region was positively correlated with the blood concentration, while the percentage of the power in the posterior β-band was negatively correlated with the concentration.