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5. Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity o

Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity o

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：edisonlin123

【摘 要】

：

To improve the pharmacological profile of tumor necrosis factor alpha(TNF-α),we have synthesized a new PEGylated prodrug,PEG-vcTNF-α,using a cathepsin B-sensi

【作 者】

：

DAI ChuanYun FU Ya LI Biao WAN 

【机 构】

：

StateKeyLaboratoryofNaturalandBiomimeticDrugs,DepartmentofBiology,InstituteofMedicinalPlantDevelopme

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2011年2期

【关键词】

：

肿瘤坏死因子-α 组织蛋白酶B 体内药代动力学 聚乙二醇化 抗癌活性 纤维肉瘤 二肽 敏感 tumor necrosis factor alpha PEGyla 

【基金项目】

：

This work was supported by the National High Technology Research and Development Program of China （Grant No. 2007AA021811）, the National Natural Science Foundation of China （Grant No. 30701055） and Po

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To improve the pharmacological profile of tumor necrosis factor alpha(TNF-α),we have synthesized a new PEGylated prodrug,PEG-vcTNF-α,using a cathepsin B-sensitive dipeptide(valine-citrulline,vc) to link branched PEG and TNF-α.PEG-modified TNF-α without th

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