目的:确立参芍双苷滴丸的最佳成型工艺。方法:采用正交试验法,以滴丸的丸形、溶散时间以及滴丸的重量差异系数为评价指标,优选药物与基质的配比、药液的温度、滴头口径以及滴速,确定最佳滴制条件。结果:最佳条件为参芍双苷原料药与基质比为1∶1.5,药液温度为80℃,滴管内外径为2.14mm/3.18mm,滴速为(30±2)滴/min。结论:本试验优选出的滴制条件切实可行,成品率高。 Objective: To establish the best forming process of Paeoniflorin pills. Methods: Orthogonal test was used to determine the pill shape, dissolution time and weight difference coefficient of dropping pills, and the ratio of drug to matrix, the temperature of the solution, the caliber of the drip and the drip rate were determined Best dropping conditions. Results: The optimum conditions were as follows: the ratio of drug substance to matrix was 1: 1.5; the temperature of the liquid was 80 ℃; the inner diameter and the outer diameter of the pipette were 2.14mm / 3.18mm; the dropping speed was (30 ± 2) drops / min. Conclusion: The conditions of this test drop out feasible, high yield.